Chronisch

myeloproliferative

Erkrankungen

Dr. Sormann Siegfried

Modyfing Mutationen

Reihenfolge

Neoplasms that acquired the JAK2 mutation prior to the TET2 mutation were more likely to present at a younger age, have clinical features of PV, and develop thrombosis. In contrast, the presence of a TET2 mutation prior to the acquisition of a JAK2 mutation may alter the impact of the JAK2 mutation, perhaps through methylation-based silencing of genes that are normally expressed

Treiber Mutationen

andere Mutationen

DNA_Methylierung

Histone

Transkriptionsfaktoren

Splicing

Vorgangsweise