Chronisch
myeloproliferative
Erkrankungen
Dr. Sormann Siegfried
Modyfing Mutationen
Reihenfolge
Neoplasms that acquired the JAK2 mutation prior to the TET2 mutation were more likely to present at a younger age, have clinical features of PV, and develop thrombosis. In contrast, the presence of a TET2 mutation prior to the acquisition of a JAK2 mutation may alter the impact of the JAK2 mutation, perhaps through methylation-based silencing of genes that are normally expressed
Treiber Mutationen
andere Mutationen
DNA_Methylierung
Histone
Transkriptionsfaktoren
Splicing